Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis.

Jiaxuan Qin, Zonglong Cai, Jinchun Xing, Bo Duan, Peide Bai

Journal: International braz j urol : official journal of the Brazilian Society of Urology 2019;45(5):901-909

PMID: 31626518

Free Full Text on International Brazilian J Urol View on PubMed

Abstract

PURPOSE

It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association.

MATERIALS AND METHODS

A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases.

RESULTS

Odds ratios and 95% confi dence intervals were used to pool the effect size. Five articles were included in our meta-analysis.

CONCLUSIONS

CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.

Address: Department of Urology Surgery, the First Affiliated Hospital of Xiamen University; Center of Diagnosis and Treatment of Urinary System Diseases, the First Affiliated Hospital of Xiamen University; the Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, the First Affiliated Hospital of Xiamen University. Xiamen, Fujian, China.; The First Clinical Medical School of Fujian Medical University. Xiamen, Fujian, China.

DOI: 10.1590/S1677-5538.IBJU.2019.0061

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MeSH Terms: Calcium, Female, Genetic Association Studies, Humans, Male, Polymorphism, Single Nucleotide, Receptors, Calcitonin, Risk Assessment, Risk Factors, Urolithiasis