Vitamin K and cystic fibrosis: A gordian knot that deserves our attention.

Gregorios Hatziparasides, Ioanna Loukou, Maria Moustaki, Konstantinos Douros

Journal: Respiratory medicine 2020;155():36-42

PMID: 31295676

Free Full Text on Elsevier Science View on PubMed

Abstract

Cystic fibrosis (CF) is an inherited genetic disorder with multiorgan involvement. Gastrointestinal tract dysfunction leads to fat and fat-soluble vitamins (A,D,E,K) malabsorption and deficiency of these vitamins. Subclinical vitamin K (VK) deficiency seems to be a common problem in CF patients. However, despite the rest of fat-soluble vitamins being routinely supplemented, this is not a universal clinical practice for VK. Inefficient levels of VK may have significant effects on blood coagulation and bone formation. There are also some data indicating that VK may play a key role on regulation of inflammation. Supplementing CF patients with VK seems rational, but the appropriate dosing regimens are still a matter of debate. This review will try to delineate the problem and communicate the latest opinions on this controversial issue.

Address: Pediatric Allergy and Respiratory Unit, 3rd Department of Pediatrics, University General Hospital "Attikon", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Cystic Fibrosis Dept, "Aghia Sophia" Children's Hospital, Athens, Greece.; Pediatric Allergy and Respiratory Unit, 3rd Department of Pediatrics, University General Hospital "Attikon", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: [email protected].

DOI: 10.1016/j.rmed.2019.07.005

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MeSH Terms: Blood Coagulation, Cystic Fibrosis, Humans, Osteogenesis, Vitamin K, Vitamin K Deficiency