Applications of Cellulose-based Materials in Sustained Drug Delivery Systems.

Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi, Yonghao Ni

Journal: Current medicinal chemistry 2019;26(14):2485-2501

PMID: 28685683

Abstract

Bio-compatible, bio-degradable, and bio-available excipients are of critical interest for drug delivery systems. Cellulose and its derivative-based excipients have been well studied due to their green/natural and unique encapsulation/binding properties. They are often used in controlled/sustained drug delivery systems. In these applications, cellulose and its derivatives function generally can modify the solubility/gelling behavior of drugs, resulting in different mechanisms for controlling the release profiles of drugs. In this paper, the current knowledge in the structure and chemistry of conventional cellulose derivatives, and their applications in drug delivery systems are briefly reviewed. The development of innovative cellulose-based materials, including micro-cellulose (MC) and nano-cellulose (NC) in the applications of sustained drug delivery, is also discussed.

Address: Center for Biocomposites and Biomaterials Processing, Department of Mechanical and Industrial Engineering, University of Toronto, 33 Willcocks St., Toronto, ON, Canada.; Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education, Tianjin 300457, China.; Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick, E3B 5A3, Canada.; Tianjin Food Safety & Low Carbon Manufacturing Collaborative Innovation Center, Tianjin, 300457, China.; Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.; Department of Chemical Engineering, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.

DOI: 10.2174/0929867324666170705143308

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MeSH Terms: Cellulose, Drug Delivery Systems, Excipients, Solubility