Nomograms predictive for oncological outcomes in malignant parotid tumours: recurrence and mortality rates of 228 patients from a single institution.

Giuditta Mannelli, Franchi Alessandro, Fasolati Martina, Cecconi Lorenzo, Alessandra Bettiol, Alfredo Vannacci, Gallo Oreste

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2022;279(9):4491-4503

PMID: 31346721

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Abstract

PURPOSE

Malignant parotid tumours are rare and multiple prognostic factors exist.

METHODS

Through a retrospective study we aimed to identify nomograms predicting recurrence and mortality rates in 228 primary parotid cancers. Patients clinical, treatment and tumour characteristics were retrospectively collected between 1980 and 2005 at our Institution. Factors predictive of disease-free-specific-survival (DSS) and overall survival (OS) were calculated by univariate and multivariate analysis. Nomograms were then constructed.

RESULTS

The 5- and 10-year DSS rates were 73% and 71.4%, and nomogram was drawn based on five parameters where perineural invasion showed the most significant predicting influence (p < 0.001). The median follow-up was of 95 months and the 5- and 10-year OS rates were 68.7% and 53.1%; six predictive variables (age, histological grade, perineural invasion, pathological lymph node status, resection margins and distant metastasis) were used to create nomogram.

CONCLUSIONS

Our nomograms provide a tailored outcome to a patient affected by malignant parotid tumour and give him/her a risk assessment for recurrence and mortality based on individual factors by a concordance index > 0.8.

Address: Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, CAP 50134, Florence, Italy. [email protected].; Department of Translational Research, University of Pisa, Pisa, Italy.; Head and Neck and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, CAP 50134, Florence, Italy.; Department of Statistic, Computer Science, Application, University of Florence, Florence, Italy.; Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, Tuscan Regional Centre of Pharmacovigilance and Phytovigilance, University of Florence, Florence, Italy.; Otorhinolaryngology Clinic, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

DOI: 10.1007/s00405-019-05556-9

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https://dx.doi.org/10.1007/s00405-019-05556-9

MeSH Terms: Female, Humans, Male, Neoplasm Recurrence, Local, Neoplasm Staging, Nomograms, Parotid Neoplasms, Prognosis, Retrospective Studies