Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy.

Arthur W D Edridge, Martin Deijs, Ruth Namazzi, Cosimo Cristella, Maarten F Jebbink, Irma Maurer, Neeltje A Kootstra, Linda R Buluma, Job B M van Woensel, Menno D de Jong, Richard Idro, Michael Boele van Hensbroek, Lia van der Hoek

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020;68(1):139-142

PMID: 29893821

Free Full Text on PubMed Central View on PubMed

Abstract

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

Address: Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam, The Netherlands.; Global Child Health Group, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.; Department of Paediatrics and Child Health, Mulago Hospital, Makerere University College of Health Sciences, Kampala, Uganda.; Laboratory of Viral Immune Pathogenesis, Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.

DOI: 10.1093/cid/ciy486

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

https://scite.ai/reports/29893821

Molecular Biology Databases:

https://www.hfv.lanl.gov/components/sequence/HCV/s...

Subscription / membership required

Full Text Sources:

Other Literature Sources:

https://facultyopinions.com/pubmed/29893821

MeSH Terms: Bunyaviridae Infections, Cerebrospinal Fluid, Child, Preschool, Encephalitis, Viral, Female, Genotype, Humans, Metagenomics, Orthobunyavirus, Uganda