A form of Autoimmune Diabetes in Adults Named LADA - An Update on Essential Features and Controversies.

Valdemar Grill, Bjørn O Åsvold

Journal: Current diabetes reviews 2019;15(3):172-173

PMID: 30009712

Abstract

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than "classical" type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

Address: Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, NO-7006 Trondheim, Norway.

DOI: 10.2174/1573399814666180716152342

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MeSH Terms: Adult, Autoantibodies, Autoimmunity, Glutamate Dehydrogenase, Humans, Latent Autoimmune Diabetes in Adults, Life Style, Risk Factors