Chemistry for Positron Emission Tomography: Recent Advances in C-, F-, N-, and O-Labeling Reactions.

Xiaoyun Deng, Jian Rong, Lu Wang, Neil Vasdev, Lei Zhang, Lee Josephson, Steven H Liang

Journal: Angewandte Chemie (International ed. in English) 2020;58(9):2580-2605

PMID: 30054961

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Abstract

Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on C, F, N, and O.

Address: Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.; Medicine Design, Pfizer Inc., Cambridge, MA, 02139, USA.

DOI: 10.1002/anie.201805501

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https://doi.org/10.1002/anie.201805501

MeSH Terms: Carbon Radioisotopes, Fluorine Radioisotopes, Humans, Isotope Labeling, Nitrogen Radioisotopes, Oxygen Radioisotopes, Positron-Emission Tomography