Biobanking of Cerebrospinal Fluid.

Randy S Tashjian, Harry V Vinters, William H Yong

Journal: Methods in molecular biology (Clifton, N.J.) 2019;1897():107-114

PMID: 30539439

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Abstract

Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. This chapter outlines the procedures necessary to collect, process, store, and utilize CSF obtained for the purposes of biobanking from both living and deceased patients.

Address: Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. [email protected].; Brain Tumor Translational Resource, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. [email protected].; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. [email protected].

DOI: 10.1007/978-1-4939-8935-5_11

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MeSH Terms: Biological Specimen Banks, Biomarkers, Brain, Cerebrospinal Fluid, Humans, Meningitis, Multiple Sclerosis, Specimen Handling