Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis.

Jiali Yang, Lingrong Wen, Yueming Jiang, Bao Yang

Journal: Trends in endocrinology and metabolism: TEM 2019;30(1):66-76

PMID: 30527917

Full Text on Elsevier Science View on PubMed

Abstract

Estrogen receptors (ERs) are transcription factors highly involved in physiological development and metabolism in the human body. They also play important roles in the treatment of cancer and metabolic diseases. Chemicals that interact with ERs can be used to treat diseases and maintain health. Phytoestrogens are natural chemicals that have been documented to possess significant ER modulatory activities. However, since phytoestrogens usually exist at low quantities in nature, heterologous biosynthesis techniques have quickly developed in recent years in order meet the demands for needed therapeutic amounts. In this review, the performance of phytoestrogens as ER modulators is described along with recent advances in biosynthesis techniques.

Address: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China.; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].

DOI: 10.1016/j.tem.2018.11.002

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MeSH Terms: Estrogen Receptor Modulators, Humans, Phytoestrogens, Receptors, Estrogen