Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis.

Mohammad Moslem Imani, Hamid Reza Mozaffari, Roohollah Sharifi, Masoud Sadeghi

Journal: Archives of oral biology 2019;98():273-279

PMID: 30579244

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

To evaluate the association between polymorphism of reduced folate carrier 1 (RFC1) A80 G in infants and the risk of non-syndromic cleft lip/palate (NSCL/P), in a meta-analysis of case-control studies.

DESIGN

We searched databases of PubMed, Scopus, Web of Science, and Cochrane Library for studies on the association of mentioned polymorphism and NSCL/P risk published until August 2018.

RESULTS

Seven articles were selected based on the criteria and were analyzed in this meta-analysis (1486 NSCL/P patients and 1596 controls). Overall, it was not obtained a significant association between the polymorphism and NSCL/P risk, with the exception of the recessive model (odds ratio = 1.45; 95% confidence interval = 1.03, 2.05; P = 0.03). A subgroup analysis showed that the frequency of GG genotype in the homozygote and recessive models in the Caucasian ethnicity was significantly higher in NSCL/P patients than in controls. Sensitivity analysis showed that the frequency of G allele and GG genotype in NSCL/P cases was significantly higher than that in controls.

CONCLUSIONS

The results identified an association between the GG genotype and NSCL/P risk and just confirmed this association in the Caucasian ethnicity. Therefore, the GG genotype of RFC1 (A80 G) polymorphism can be related to NSCL/P risk in some ethnicities more than others.

Address: Department of Orthodontics, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: [email protected].

DOI: 10.1016/j.archoralbio.2018.12.005

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MeSH Terms: Alleles, Cleft Lip, Databases, Factual, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Infant, Palate, Polymorphism, Genetic, Reduced Folate Carrier Protein