Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Plain Language Summary

Plant-based multivitamin/mineral and phytonutrient (PMP) supplementation has been reported to reduce oxidative stress, thus alleviating many chronic diseases, though inconsistent results have been published. The aim of this randomised, double-blind, parallel-arm, placebo-controlled trial was to determine the antioxidant and protective capacity of a PMP supplementation in 96 healthy adults with habitually low fruit and vegetable intake. After a two-week run in period, participants were randomised to consume either a PMP supplement or colour-matched control for eight weeks. The PMP supplement contained 14 vitamins, 10 minerals and 22 phytonutrient extracts. Blood was taken at baseline and conclusion of the intervention period. This study found that after an eight-week PMP supplementation, several plasma vitamins and phytonutrients were associated with reduced markers of oxidation and DNA damage compared to the control group. Based on these results, the authors conclude PMP supplement may support the body's ability to handle oxidative stress and suggest further research be conducted to better understand the role mechanisms action of phytonutrients.