Vitamin K in Chronic Kidney Disease.

Mario Cozzolino, Michela Mangano, Andrea Galassi, Paola Ciceri, Piergiorgio Messa, Sagar Nigwekar

Journal: Nutrients 2019;11(1):168

PMID: 30646590

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Abstract

Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme γ-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.

Address: Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy. [email protected].; Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy. [email protected].; Renal Division, Department of Health Sciences, University of Milan, 20142 Milan, Italy. [email protected].; Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy. [email protected].; Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, 20122 Milan, Italy. [email protected].; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA 02114, USA. [email protected].

DOI: 10.3390/nu11010168

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MeSH Terms: Bone and Bones, Carbon-Carbon Ligases, Dietary Supplements, Humans, Nutritional Status, Randomized Controlled Trials as Topic, Renal Insufficiency, Chronic, Vitamin K, Vitamin K Deficiency, Warfarin