A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

Address: Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.; The Framingham Heart Study, Framingham, MA.; Center for Population Genomics, Veterans Affairs (VA) Boston Healthcare System, Jamaica Plain, MA.; Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.; The Framingham Heart Study, Framingham, MA.; Department of Medical Sciences and.; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN.; Department of Biostatistics, University of Washington, Seattle, WA.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.; The Framingham Heart Study, Framingham, MA.; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.; National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC.; Department of Medicine, University of Washington, Seattle, WA.; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Epidemiology and Biostatistics and.; Department of Stroke Medicine, Imperial College London, London, United Kingdom.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Institute of Nutrition, Friedrich Schiller University Jena, Mannheim, Germany.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.; Royal North Shore Hospital, University of Sydney, Sydney, Australia.; The Framingham Heart Study, Framingham, MA.; Department of Neurology, Boston University, Boston, MA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, College of Medicine, Baylor University, Houston, TX.; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, School of Medicine, University of Maryland, Baltimore, MD.; Baltimore VA Medical Center, Baltimore, MD.; Department of Medicine.; Department of Epidemiology, and.; Department of Health Services, University of Washington, Seattle, WA.; Kaiser Permanente Washington Research Institute, Kaiser Permanente Washington, Seattle, WA.; Fred Hutchinson Cancer Research Center, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.; Unitat d'Hemostasia i Trombosi, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology and Biostatistics and.; MRC-Public Health England Centre for Environment and Health, School of Public Health and.; UK Dementia Research Institute, Imperial College London, London, United Kingdom.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.; Cardiology Section, VA Boston Healthcare System, West Roxbury, MA; and.; Kaiser Permanente Washington Research Institute, Kaiser Permanente Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Seattle Epidemiologic Research and Information Center, Office of Research and Development, Department of Veteran Affairs, Seattle, WA.