Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase () hypomorphic variants.

Tenghao Zheng, Shanti Eswaran, Amanda L Photenhauer, Juanita L Merchant, William D Chey, Mauro D'Amato

Journal: Gut 2020;69(2):397-398

PMID: 30658996

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Abstract

Address: Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Division of Gastroenterology, Michigan Medicine, Ann Arbor, Michigan, USA.; Division of Gastroenterology, University of Arizona, Tucson, Arizona, USA.; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Departmentof Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastián, Spain.; IKERBASQUE, Basque Science Foundation, Bilbao, Spain.

DOI: 10.1136/gutjnl-2018-318036

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MeSH Terms: Adult, Diet, Carbohydrate-Restricted, Female, Genetic Variation, Genotype, Humans, Irritable Bowel Syndrome, Male, Middle Aged, Prognosis, Sucrase-Isomaltase Complex, Treatment Outcome