Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Ralf Fliegert, Jörg Heeren, Friedrich Koch-Nolte, Viacheslav O Nikolaev, Christian Lohr, Chris Meier, Andreas H Guse

Journal: Biochemical Society transactions 2019;47(1):329-337

PMID: 30674608

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Abstract

Adenine nucleotides (AdNs) play important roles in immunity and inflammation. Extracellular AdNs, such as adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD) and their metabolites, act as paracrine messengers by fine-tuning both pro- and anti-inflammatory processes. Moreover, intracellular AdNs derived from ATP or NAD play important roles in many cells of the immune system, including T lymphocytes, macrophages, neutrophils and others. These intracellular AdNs are signaling molecules that transduce incoming signals into meaningful cellular responses, e.g. activation of immune responses against pathogens.

Address: Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; Department of Immunology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; Department of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; Institute of Zoology, University of Hamburg, Martin-Luther-King Platz 3, 20146 Hamburg, Germany.; Organic Chemistry, University of Hamburg, Martin-Luther-King Platz 6, 20146 Hamburg, Germany.; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany [email protected].

DOI: 10.1042/BST20180419

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MeSH Terms: Adenine Nucleotides, Adenosine Triphosphate, Humans, Inflammation, Macrophages, NAD, Neutrophils, Paracrine Communication, Second Messenger Systems, Signal Transduction, T-Lymphocytes