Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obregón, Hermosillo and rural Sonora.

María Guadalupe Uribe-Duarte, Jesús Abraham Aguilar-Campos, Rodrigo Barquera, Alicia Bravo-Acevedo, Stephen Clayton, Esteban Arrieta-Bolaños, María de Jesús Ruíz-Corral, Diana Iraíz Hernández-Zaragoza, Ricardo Serrano-Osuna, Edmond J Yunis, Joaquín Zúñiga, Carolina Bekker-Méndez, Julio Granados

Journal: Human immunology 2021;81(9):478-481

PMID: 31174914

Full Text on Elsevier Science View on PubMed

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 439 Mexicans from the state of Sonora living in Ciudad Obregón (N = 143), Hermosillo (N = 99), and rural communities (N = 197) to obtain information regarding allelic and haplotypic frequencies. We find that the 13 most frequent haplotypes for the state of Sonora include nine Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Sonora are European (51.25 ± 2.90% by ML; 37.70% of European haplotypes) and Native American (43.35 ± 2.57% by ML; 39.64% of Native American haplotypes), while the African genetic component was less apparent (5.39 ± 2.54% by ML; 11.04% of African haplotypes).

Address: Clinical Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 2, Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, Sonora, Mexico.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: [email protected].; Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany.; Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias (INER) Ismael Cosío Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.; Immunology and Infectology Research Unit, Infectology Hospital, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.; Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" (INCMNSZ), Mexico City, Mexico.

DOI: 10.1016/j.humimm.2019.05.013

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MeSH Terms: Alleles, Ethnicity, Gene Frequency, Genetic Variation, Genetics, Population, Geography, Medical, HLA Antigens, Haplotypes, Humans, Mexico