Folate as an Adjuvant Therapy in Methanol Poisoning.

Jillian Theobald, Christopher Lim

Journal: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2020;34(4):521-527

PMID: 31172585

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Abstract

Folate and its derivatives have long been used as an adjunctive treatment in methanol poisoning. Methanol is ultimately metabolized to formate, the toxic compound. The accumulation of formate can lead to acidemia, retinal damage, visual impairment, and death. Formate is converted to carbon dioxide and water in a folate-dependent manner, and folate is often given in cases of methanol poisoning. In this paper, the evidence for folate as an adjunctive therapy in methanol poisoning is reviewed.

Address: Department of Emergency Medicine, Division of Medical Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Emergency Medicine, Kaiser Permanente San Jose Medical Center, San Jose, California, USA.

DOI: 10.1002/ncp.10329

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MeSH Terms: Chemotherapy, Adjuvant, Folic Acid, Humans, Methanol, Poisoning, Vitamin B Complex