Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa.

Stephen Clayton, Rodrigo Barquera, María Guadalupe Uribe-Duarte, Isis Goné Vázquez, Joaquín Zúñiga, Esteban Arrieta-Bolaños, Diana Iraíz Hernández-Zaragoza, María de Jesús Ruíz-Corral, Araceli Escobedo-Ruíz, Francia Paulina Arellano-Prado, Víctor Eduardo García-Arias, Marla Estefanía Rodríguez-López, Alicia Bravo-Acevedo, María Guadalupe de Jesús Sánchez-Fernández, Jesús Abraham Aguilar-Campos, Ricardo Serrano-Osuna, Benjamín Gómez-Navarro, Mario J Sandoval-Sandoval, Edmond J Yunis, Carolina Bekker-Méndez, Julio Granados

Journal: Human immunology 2021;81(9):482-484

PMID: 31201081

Full Text on Elsevier Science View on PubMed

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47%) and Native American (37.61 ± 2.85%), while the African genetic component was estimated as virtually absent (0.00 ± 1.86%).

Address: Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History (MPI-SHH), Jena, Germany; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Electronic address: [email protected].; Clinical Laboratory, Unidad Médica de Alta Especialidad (UMAE) # 2, Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, Sonora, Mexico.; Histocompatibility Laboratory, Specialty Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias (INER) Ismael Cosío Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.; Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.; Molecular Genetics Laboratory, Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico; Immunogenetics Unit, Técnicas Genéticas Aplicadas a la Clínica (TGAC), Mexico City, Mexico.; Pediatrics Hospital, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.; Blood Bank, UMAE Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.; Department of Nephrology and Transplantation Unit, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.; Central Office of Nephrology, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.; Central Office of Transplantation, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Immunology and Infectology Research Unit, Infectology Hospital, Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico. Electronic address: [email protected].; Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" (INCMNSZ), Mexico City, Mexico.

DOI: 10.1016/j.humimm.2019.06.006

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MeSH Terms: Alleles, Ethnicity, Gene Frequency, Genetic Variation, Genetics, Population, Genotype, Geography, HLA Antigens, Haplotypes, Humans, Immunogenetics, Mexico, Rural Population