Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer.

Andrea Csonka, Annamária Kincses, Márta Nové, Zsófia Vadas, Carmen Sanmartín, Enrique Domínguez-Álvarez, Gabriella Spengler

Journal: Anticancer research 2019;39(7):3777-3783

PMID: 31262904

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Abstract

BACKGROUND/AIM

Selenium-containing compounds are becoming new alternatives in experimental chemotherapy in order to overcome multidrug resistance in cancer. The main goal of this study was to determine whether combined treatment with new Se-compounds would increase the effect of conventional doxorubicin chemotherapy in breast cancer cell lines.

MATERIALS AND METHODS

Se-compounds were evaluated regarding their cytotoxic and apoptosis-inducing effect on MCF-7 and ATP-binding cassette subfamily B member 1 (ABCB1)-overexpressing KCR breast cancer cell lines. Moreover, the interaction of Se-compounds with doxorubicin was assessed using the MTT assay.

RESULTS

Selenoanhydride exerted a selective activity towards the doxorubicin-resistant KCR cell line overexpressing ABCB1. Among the selenoesters, only ketone-containing selenoesters exerted significant cytotoxic activity against MCF-7 and KCR cell lines and the Se-compounds acted synergistically with doxorubicin on the KCR cell line.

CONCLUSION

The importance of the COSeCHCOCH and COSeCHCO(CH) moieties for the cytotoxic and adjuvant role of Se-compounds was highlighted.

Address: Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Szeged, Hungary.; Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.; Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain.; Institute of General Organic Chemistry, Spanish National Research Council (IQOG-CSIC), Madrid, Spain.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary [email protected].

DOI: 10.21873/anticanres.13526

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MeSH Terms: Anhydrides, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Cell Survival, Doxorubicin, Drug Resistance, Neoplasm, Esters, Female, Humans, Selenium Compounds