Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha.

R E Kast

Journal: International immunopharmacology 2002;1(12):2197-9

PMID: 11710548

Full Text on Elsevier Science View on PubMed

Abstract

Recent double blind studies have shown some benefit of borage oil in treatment of rheumatoid arthritis. Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is reviewed that indicates gamma linolenic acid component of borage oil increases prostaglandin E levels that increase cAMP levels that in turn suppress tumor necrosis factor-alpha synthesis. If this biochemical path of borage oil is correct then (1) concomitant non-steroidal anti-inflammatory drug use would tend to undermine borage oil effects, and (2) borage oil would be contraindicated in pregnancy given the teratogenic and labor inducing effects of prostaglandin E agonists.

Address: Department of Psychiatry, College of Medicine, University of Vermont, Burlington 05401, USA. [email protected]

DOI: 10.1016/s1567-5769(01)00146-1

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MeSH Terms: Abortion, Spontaneous, Alprostadil, Anti-Inflammatory Agents, Non-Steroidal, Antirheumatic Agents, Arthritis, Rheumatoid, Borago, Contraindications, Cyclic AMP, Dinoprostone, Double-Blind Method, Drug Interactions, Female, Humans, Phytotherapy, Plant Oils, Pregnancy, Randomized Controlled Trials as Topic, Second Messenger Systems, Tumor Necrosis Factor-alpha, gamma-Linolenic Acid