Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies.

Yuki Hashimoto, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Kousuke Noda, Atsuhiro Kanda, Susumu Ishida

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2019;257(8):1751-1758

PMID: 31065846

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Abstract

PURPOSE

To compare the clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease patients with and without anti-retinal antibodies (ARAs) that are frequently detected in autoimmune retinopathy.

METHODS

Using immunoblot analyses, serum autoantibodies for recoverin, carbonic anhydrase II, and α-enolase were examined in 20 treatment-naïve patients with VKH disease. Clinical factors before and after systemic corticosteroid therapy, including best-corrected visual acuity (BCVA) and macular outer retinal morphology, were statistically compared between patients with VKH disease with and without ARAs.

RESULTS

Serum ARAs were detected in 50.0% of patients with VKH disease. There were no significant differences in clinical factors between the two groups, including final BCVA, frequency of uveitis recurrence, and recovery of the macular ellipsoid zone after systemic corticosteroid therapy.

CONCLUSIONS

Our results suggest that the detected ARAs did not influence visual outcomes, the chronicity of uveitis, or outer retinal morphology in patients with VKH disease.

Address: Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan.; Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan. [email protected].; Kaimeido Eye and Dental Clinic, Sapporo, Japan. [email protected].

DOI: 10.1007/s00417-019-04330-1

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https://dx.doi.org/10.1007/s00417-019-04330-1

MeSH Terms: Adolescent, Adult, Autoantibodies, Carbonic Anhydrase II, Child, Female, Glucocorticoids, Humans, Immunoblotting, Male, Middle Aged, Phosphopyruvate Hydratase, Prognosis, Recoverin, Retina, Retrospective Studies, Tomography, Optical Coherence, Uveomeningoencephalitic Syndrome, Visual Acuity, Young Adult