Bioelectrocatalytic performance of d-fructose dehydrogenase.

Taiki Adachi, Yuya Kaida, Yuki Kitazumi, Osamu Shirai, Kenji Kano

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 2019;129():1-9

PMID: 31063949

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Abstract

This review summarizes the bioelectrocatalytic properties of d-fructose dehydrogenase (FDH), while taking into consideration its enzymatic characteristics. FDH is a membrane-bound flavohemo-protein with a molecular mass of 138 kDa, and it catalyzes the oxidation of d-fructose to 5-keto-d-fructose. The characteristic feature of FDH is its strong direct-electron-transfer (DET)-type bioelectrocatalytic activity. The pathway of the DET-type reaction is discussed. An overview of the application of FDH-based bioelectrocatalysis to biosensors and biofuel cells is also presented, and the benefits and problems associated with it are extensively discussed.

Address: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606-8502, Japan.; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606-8502, Japan. Electronic address: [email protected].

DOI: 10.1016/j.bioelechem.2019.04.024

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MeSH Terms: Amino Acid Sequence, Bacteria, Biocatalysis, Bioelectric Energy Sources, Biosensing Techniques, Carbohydrate Dehydrogenases, Electron Transport, Fructose, Oxidation-Reduction