Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach.

Fatemeh Forouzanfar, George Barreto, Muhammed Majeed, Amirhossein Sahebkar

Journal: BioFactors (Oxford, England) 2020;45(5):631-640

PMID: 31136038

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

Address: Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Departamento de Nutrición yBioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.; Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.; Sabinsa Corporation, East Windsor, New Jersey.; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Biotechnology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.1002/biof.1522