Chitosan/glycosaminoglycan scaffolds for skin reparation.

Giuseppina Sandri, Silvia Rossi, Maria Cristina Bonferoni, Dalila Miele, Angela Faccendini, Elena Del Favero, Emanuela Di Cola, Antonia Icaro Cornaglia, Cinzia Boselli, Thomas Luxbacher, Lorenzo Malavasi, Laura Cantu', Franca Ferrari

Journal: Carbohydrate polymers 2019;220():219-227

PMID: 31196543

Free Full Text on Archivio Istituzionale della Ricerca Unimi - Access Free Full Text View on PubMed

Abstract

Burns and chronic wounds, often related to chronic diseases (as diabetes and cancer), are challenging lesions, difficult to heal. The prompt and full reconstitution of a functional skin is at the basis of the development of biopolymer-based scaffolds, representing a 3D substrate mimicking the dermal extracellular matrix. Aim of the work was to develop scaffolds intended for skin regeneration, according to: fabrication by electrospinning from aqueous polysaccharide solutions; prompt and easy treatment to obtain scaffolds insoluble in aqueous fluids; best performance in supporting wound healing. Three formulations were tested, based on chitosan (CH) and pullulan (P), associated with glycosaminoglycans (chondroitin sulfate - CS or hyaluronic acid - HA). A multidisciplinary approach has been used: chemico-physical characterization and preclinical evaluation allowed to obtain integrated information. This supports that CS gives distinctive properties and optimal features to the scaffold structure for promoting cell proliferation leading tissue reparation towards a complete skin restore.

Address: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. Electronic address: [email protected].; Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate Milano Italy.; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini 2, 27100 Pavia, Italy.; Anton Paar GmbH, Anton-Paar-Str, 20 8054 Graz, Austria.; Department of Chemistry, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate Milano Italy. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2019.05.069

Link outs

Free resources

Full Text Sources:

https://air.unimi.it/handle/2434/647860

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0144...

MeSH Terms: Biocompatible Materials, Burns, Chitosan, Chondroitin Sulfates, Glucans, Humans, Hyaluronic Acid, Skin, Artificial, Tissue Engineering, Tissue Scaffolds, Wound Healing