Sleep and rheumatic diseases.

Tobias Boeselt, Rembert Koczulla, Christoph Nell, Bjoern Beutel, Konrad Guenter, Werner Cassel, Olaf Hildebrandt, Ulrich Koehler, Johannes Kroenig

Journal: Best practice & research. Clinical rheumatology 2020;33(3):101434

PMID: 31703798

Full Text on Elsevier Science View on PubMed

Abstract

This review article discusses various forms of sleep disorders associated with musculoskeletal diseases (MD). It presents the pathophysiology and interaction of sleep-related disorders and MD and summarizes clinical symptoms and therapies from a somnological perspective. BACKGROUND: A large number of patients suffering from MD report fragmented sleep with poor overall sleep quality. Sleep disorders often lead to increased symptoms such as daytime fatigue, depression, or increased pain intensity. In contrast, the perception of pain worsens the quality of sleep. Sleep is a complex regulation of hormonal and neuromodulatory influences to maintain regenerative processes and signal processing. Furthermore, interleukins (e.g., IL-6 and TNFα), messenger substances, or inflammatory markers (e.g., CRP) may have a regulatory influence on sleep. THERAPY: Sleep disorders in MD can often be treated with behavioral therapies or drug approaches. Another and very important influence is physical activity. In combination with training, regular physical activity can lead, for instance, to improved sleep quality, endurance performance, and reduced inflammation values. The change of lifestyle with regard to activity and nutrition is another key concept in the optimal therapy of patients with MD.

Address: Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany; Pulmonology Schoen Clinic Berchtesgadener Land, Teaching Hospital of Philipps-University of Marburg, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].; Philipps-University of Marburg/ Institute for Internal Medicine, Department of Pulmonology, Marburg, Hessen, Germany. Electronic address: [email protected].

DOI: 10.1016/j.berh.2019.101434