Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases.

Leila Rezig, Imen Ghzaiel, Mohamed Ksila, Aline Yammine, Thomas Nury, Amira Zarrouk, Mohammad Samadi, Moncef Chouaibi, Anne Vejux, Gérard Lizard

Journal: Steroids 2022;187():109093

PMID: 36029811

Full Text on Elsevier Science View on PubMed

Abstract

7-ketocholesterol and 7β-hydroxycholesterol are two oxysterols mainly formed by the autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes. These two oxysterols are often observed at increased amounts in biological fluids as well as tissues and organs affected during age-related diseases and in diseases of civilization such as cardiovascular, neurodegenerative, and ocular diseases as well as type 2 diabetes and metabolic syndrome. Noteworthy, 7-ketocholesterol and 7β-hydroxycholesterol induce oxidative stress and inflammation, which are frequently observed in patients with age-related and civilization diseases. For this reason, the involvement of these two oxysterols in the pathophysiology of these diseases is widely suspected. In addition, the toxicity of these oxysterols can lead to death by oxiapoptophagy characterized by oxidative stress, apoptosis induction and autophagy criteria. To prevent, or even treat, certain age-related or civilization diseases associated with increased levels of 7-ketocholesterol and 7β-hydroxycholesterol, the identification of molecules or mixtures of molecules attenuating or inhibiting the toxic effects of these oxysterols allows to consider new treatments. In this context, many nutrients present in significant amounts in the Mediterranean diet, especially tocopherols, fatty acids, and polyphenols, have shown cytoprotective activities as well as several Mediterranean oils (argan and olive oils, milk thistle seed oil, and pistacia lentiscus seed oil). Consequently, a nutraceutical approach, rich in nutrients present in the Mediterranean diet, could thus make it possible to counteract certain age-related and civilization diseases associated with increased levels of 7-ketocholesterol and 7β-hydroxycholesterol.

Address: University of Carthage, National Institute of Applied Sciences and Technology, LR11ES26, LIP-MB 'Laboratory of Protein Engineering and Bioactive Molecules', Tunis 1080, Tunisia; University of Carthage, High Institute of Food Industries, 58 Alain Savary Street, El Khadra City, Tunis 1003, Tunisia. Electronic address: [email protected].; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270), University of Bourgogne/Inserm, Dijon 21000, France; University of Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir 5000, Tunisia; University Tunis-El Manar, Faculty of Sciences of Tunis, Tunis 2092, Tunisia.; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270), University of Bourgogne/Inserm, Dijon 21000, France; Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules, (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis 2092, Tunisia.; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270), University of Bourgogne/Inserm, Dijon 21000, France; Institut Européen des Antioxydants (IEA), 1B, rue Victor de Lespinats, Neuves-Maisons 54230, France.; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270), University of Bourgogne/Inserm, Dijon 21000, France.; University of Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Monastir 5000, Tunisia; Laboratory of Biochemistry, Faculty of Medicine, University of Sousse, Sousse 4000, Tunisia.; LCPMC-A2, ICPM, Department of Chemistry, University Lorraine, Metz Technopôle, Metz 57070, France.; University of Carthage, High Institute of Food Industries, 58 Alain Savary Street, El Khadra City, Tunis 1003, Tunisia; University of Carthage, Bio-preservation and Valorization of Agricultural Products UR13-AGR 02, High Institute of Food Industries, 58 Alain Savary Street, El Khadra City, Tunis 1003, Tunisia.; Team Bio-PeroxIL, Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270), University of Bourgogne/Inserm, Dijon 21000, France. Electronic address: [email protected].

DOI: 10.1016/j.steroids.2022.109093

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MeSH Terms: Aging, Civilization, Diabetes Mellitus, Type 2, Diet, Mediterranean, Fatty Acids, Humans, Hydroxycholesterols, Ketocholesterols, Nutrients, Oils, Olive Oil, Polyphenols, Tocopherols