The role of occupational Aspergillus exposure in the development of diseases.

Raquel Sabino, Cristina Veríssimo, Carla Viegas, Susana Viegas, João Brandão, Magna Alves-Correia, Luís-Miguel Borrego, Karl V Clemons, David A Stevens, Malcolm Richardson

Journal: Medical mycology 2019;57(Supplement_2):S196-S205

PMID: 30816970

Abstract

Aspergillus spp. have a high nutritional versatility and good growth on a large variety of construction materials. They also colonize soil or food, but decaying vegetation is their primary ecological niche. Therefore, exposure to fungi may occur at home, during hospitalization, during specific leisure activities, or at the workplace. The development of Aspergillus infections depends on the interplay between host susceptibility and the organism. Environments with high counts of fungal elements (conidia, hyphal fragments and others), high levels of bioarerosols, and elevated concentrations of mycotoxins or other volatile organic compounds should be considered as potential hazards, since they may present a risk to the exposed person. Rural tasks as well as work related to wood and food industries, poultries, swineries, waste handling plants, and other occupational environments involving contaminated organic material are among the ones posing higher respiratory risks to the workers. This paper presents a review of several studies related to occupational and indoor exposure to Aspergillus, potential health effects related to that exposure, and associated exposure assessment procedures.

© The Author(s) 2019. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.

Address: Nacional Institute of Health Dr. Ricardo Jorge - URSZ- Infectious Diseases Department, Lisbon, Portugal.; Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa.; H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa.; Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa.; Nacional Institute of Health Dr. Ricardo Jorge - Department of Environmental Health, Lisbon, Portugal.; Allergy Unit, CUF Descobertas Hospital, Lisbon.; The Chronic Diseases Research Center, CEDOC, NOVA Medical School / Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, United States.; California Institute for Medical Research, San Jose, California, United States.; Mycology Reference Centre, Manchester University NHS Foundation Trust.; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, United Kingdom.

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