Experimental and theoretical tools to elucidate the binding mechanisms of solid-binding peptides.

Rachit Bansal, Andrew Care, Megan S Lord, Tiffany R Walsh, Anwar Sunna

Journal: New biotechnology 2019;52():9-18

PMID: 30954671

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Abstract

The interactions between biomolecules and solid surfaces play an important role in designing new materials and applications which mimic nature. Recently, solid-binding peptides (SBPs) have emerged as potential molecular building blocks in nanobiotechnology. SBPs exhibit high selectivity and binding affinity towards a wide range of inorganic and organic materials. Although these peptides have been widely used in various applications, there is a need to understand the interaction mechanism between the peptide and its material substrate, which is challenging both experimentally and theoretically. This review describes the main characterisation techniques currently available to study SBP-surface interactions and their contribution to gain a better insight for designing new peptides for tailored binding.

Address: Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia; ARC Centre of Excellence for Nanoscale Biophotonics, Macquarie University, Sydney, NSW 2109, Australia.; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.; Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.; Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia; ARC Centre of Excellence for Nanoscale Biophotonics, Macquarie University, Sydney, NSW 2109, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: [email protected].

DOI: 10.1016/j.nbt.2019.04.001

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MeSH Terms: Amino Acid Sequence, Biophysical Phenomena, Models, Molecular, Peptides, Protein Binding