Coumarins and P450s, Studies Reported to-Date.

Maryam Foroozesh, Jayalakshmi Sridhar, Navneet Goyal, Jiawang Liu

Journal: Molecules (Basel, Switzerland) 2019;24(8):1620

PMID: 31022888

Abstract

Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosynthesis of endogenous compounds and the bioactivation of xenobiotics. Coumarins, phytochemicals abundant in food and commonly used in fragrances and cosmetics, have been shown to interact with P450 enzymes as substrates and/or inhibitors. In this review, these interactions and their significance in pharmacology and toxicology are discussed in detail.

Address: Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. [email protected].; Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. [email protected].; Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA. [email protected].; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., Memphis, TN 38163, USA. [email protected].

DOI: 10.3390/molecules24081620

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MeSH Terms: Coumarins, Cytochrome P-450 Enzyme System, Humans, Metabolic Detoxication, Phase I, Models, Molecular, Quantitative Structure-Activity Relationship, Xenobiotics