Cardiac sympathetic innervation scintigraphy with I-meta-iodobenzylguanidine. Basis, protocols and clinical applications in Cardiology.

I Casáns-Tormo, A Jiménez-Heffernan, V Pubul-Núñez, R Ruano-Pérez

Journal: Revista espanola de medicina nuclear e imagen molecular 2020;38(4):262-271

PMID: 31031167

Full Text on Elsevier Science View on PubMed

Abstract

Imaging of cardiac sympathetic innervation is only possible by nuclear cardiology techniques and its assessment is key in the evaluation of and decision-making for patients with cardiac sympathetic impairment. This review includes the basis of cardiac sympathetic scintigraphy with I-meta-iodobenzylguanidine (I-MIBG), recommended protocols, patient preparation, image acquisition and quantification, reproducibility, dosimetry, etc., and also the clinical indications for cardiac patients, mainly with regard to heart failure, arrhythmia, coronary artery disease, cardiotoxicity, including its contribution to establishing the indication for and monitoring the response to implantable cardiac devices, pharmacological treatment, heart transplantation and other.

Address: Servicio de Medicina Nuclear, Hospital Clínico Universitario, Valencia, España; Grupo de Trabajo de Cardiología Nuclear de la Sociedad Española de Medicina Nuclear e Imagen Molecular. Electronic address: [email protected].; Grupo de Trabajo de Cardiología Nuclear de la Sociedad Española de Medicina Nuclear e Imagen Molecular; Servicio de Medicina Nuclear, Hospital Universitario Juan Ramón Jiménez, Huelva, España.; Grupo de Trabajo de Cardiología Nuclear de la Sociedad Española de Medicina Nuclear e Imagen Molecular; Servicio de Medicina Nuclear, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, España.; Grupo de Trabajo de Cardiología Nuclear de la Sociedad Española de Medicina Nuclear e Imagen Molecular; Servicio de Medicina Nuclear, Hospital Clínico Universitario, Valladolid, España.

DOI: 10.1016/j.remn.2019.01.001

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MeSH Terms: 3-Iodobenzylguanidine, Cardiac Resynchronization Therapy Devices, Child, Preschool, Clinical Decision-Making, Defibrillators, Implantable, Heart, Heart Conduction System, Heart Diseases, Heart Transplantation, Humans, Image Processing, Computer-Assisted, Infusions, Intravenous, Iodine Radioisotopes, Norepinephrine, Perchlorates, Potassium Compounds, Prognosis, Radiometry, Radiopharmaceuticals, Receptors, Adrenergic, Reproducibility of Results, Sympathetic Nervous System, Thyroid Gland, Treatment Outcome