Med15: Glutamine-Rich Mediator Subunit with Potential for Plasticity.

David G Cooper, Jan S Fassler

Journal: Trends in biochemical sciences 2020;44(9):737-751

PMID: 31036407

Full Text on Elsevier Science View on PubMed

Abstract

The Mediator complex is required for basal activity of the RNA polymerase (Pol) II transcriptional apparatus and for responsiveness to some activator proteins. Med15, situated in the Mediator tail, plays a role in transmitting regulatory information from distant DNA-bound transcription factors to the transcriptional apparatus poised at promoters. Yeast Med15 and its orthologs share an unusual, glutamine-rich amino acid composition. Here, we discuss this sequence feature and the tendency of polyglutamine tracts to vary in length among strains of Saccharomyces cerevisiae, and we propose that different polyglutamine tract lengths may be adaptive within certain domestication habitats.

Address: Department of Biology, University of Iowa, Iowa City, IA 52242, USA.; Department of Biology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2019.03.008

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MeSH Terms: Mediator Complex, Peptides, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins