Tissue Engineering: What is New?

Dolphus R Dawson, Ahmed El-Ghannam, Joseph E Van Sickels, Noel Ye Naung

Journal: Dental clinics of North America 2019;63(3):433-445

PMID: 31097136

Full Text on Elsevier Science View on PubMed

Abstract

Soft and hard tissue engineering has expanded the frontiers of oral/maxillofacial augmentation. Soft tissue grafting enhancements include improving flap prevascularization and using stem cells and other cells to create not only the graft, but also the vascularization and soft tissue scaffolding for the graft. Hard tissue grafts have been enhanced by osteoinductive factors, such as bone morphogenic proteins, that have allowed the elimination of harvesting autogenous bone and thus decrease the need for other surgical sites. Advancements in bone graft scaffolds have developed via seeding with stem cells and improvement of the silica/calcium/phosphate composite to improve graft characteristics and healing.

Address: Division of Periodontology, Department of Oral Health Practice, College of Dentistry, University of Kentucky, 800 Rose Street, D-444 Dental Sciences Building, Lexington, KY 40536-0297, USA. Electronic address: [email protected].; Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223-0001, USA.; Division of Oral and Maxillofacial Surgery, College of Dentistry, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0297, USA.

DOI: 10.1016/j.cden.2019.02.009

Link outs

Free resources

Medical:

https://medlineplus.gov/bonegrafts.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Bone Transplantation, Humans, Surgical Flaps, Tissue Engineering, Tissue Scaffolds