The effects of mobile health interventions on lipid profiles among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.

Maryam Akbari, Kamran B Lankarani, Ahmad Naghibzadeh-Tahami, Reza Tabrizi, Behnam Honarvar, Fariba Kolahdooz, Vahidreza Borhaninejad, Zatollah Asemi

Journal: Diabetes & metabolic syndrome 2019;13(3):1949-1955

PMID: 31235120

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of mobile health (m-health) interventions on lipid profiles among patients with metabolic syndrome and related disorders.

METHODS

Cochrane Library, EMBASE, PubMed, and Web of Science databases were searched to indentify the relevant randomized clinical trials published up April 30, 2018. Two reviewers examined study eligibility, extracted data, and assessed risk of bias of included clinical trials, individually. Heterogeneity was measured using I-square (I) statistic and Cochran's Q test. Data were pooled the standardized mean difference (SMD) effect size by the random-effect model.

RESULTS

18 trials of 1681 citations were identified to be appropriate for the current meta-analysis. Findings random-effects model indicated that m-health interventions significantly decreased total- (SMD -0.54; 95% CI, -1.05, -0.03) and LDL-cholesterol levels (SMD -0.66; 95% CI, -1.18, -0.15). M-health interventions had no significant effect on triglycerides (SMD -0.14; 95% CI, -0.56, 0.28) and HDL-cholesterol levels (SMD -0.35; 95% CI, -0.81, 0.11).

CONCLUSION

Overall, the current meta-analysis demonstrated that m-health interventions resulted in an improvement in total- and LDL-cholesterol, but did not affect triglycerides and HDL-cholesterol levels.

Address: Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.; Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, 3Kerman University of Medical Sciences, Kerman, Iran.; Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran; Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada.; Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran. Electronic address: [email protected].

DOI: 10.1016/j.dsx.2019.04.011

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MeSH Terms: Dietary Supplements, Early Intervention, Educational, Humans, Lipids, Metabolic Syndrome, Randomized Controlled Trials as Topic, Telemedicine