Parenteral Nutrition Drug Shortages: A Single-Center Experience With Rapid Process Change.

Erin M Nystrom, Whitney J Bergquist, Patrick M Wieruszewski, M Molly McMahon, Erin F Barreto

Journal: JPEN. Journal of parenteral and enteral nutrition 2020;43(5):583-590

PMID: 31531869

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Abstract

Disruptions in the medication supply chain and consequent drug product shortages, including shortages of parenteral products used for parenteral nutrition (PN) compounding, have become an increasingly common occurrence. The amino acid solution shortage that resulted from the devastating impact of Hurricanes Maria and Irma on manufacturing facilities in Puerto Rico in 2017 necessitated a rapid, coordinated shift from use of compounded PN to commercial multichamber-bag PN (MCB-PN) at our hospitals. We describe our experience operationalizing this intervention via a framework that may be adapted for addressing other drug product shortages to promote rapid yet safe use of therapeutic alternatives.

Address: Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.; Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

DOI: 10.1002/jpen.1538

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MeSH Terms: Hospitals, Humans, Parenteral Nutrition, Parenteral Nutrition Solutions, Patient Safety