Gene-function studies in systemic lupus erythematosus.

Florencia Rosetti, Abigail de la Cruz, José C Crispín

Journal: Current opinion in rheumatology 2020;31(2):185-192

PMID: 30672908

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

PURPOSE OF REVIEW

The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

RECENT FINDINGS

Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis.

SUMMARY

The work discussed in this review has broad implications for our understanding of the pathogenesis of SLE and for the development of novel therapeutic strategies.

Address: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.; Plan de Estudios Combinados en Medicina (PECEM), Facultad de Medicina, UNAM, Mexico City, Mexico.

DOI: 10.1097/BOR.0000000000000572

Link outs

Free resources

Medical:

https://medlineplus.gov/genesandgenetherapy.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-BRIP1-5

Subscription / membership required

Full Text Sources:

MeSH Terms: CD11b Antigen, Gene Expression Regulation, Genetic Predisposition to Disease, Genetic Therapy, Humans, Lupus Erythematosus, Systemic, RNA