Pharmacogenetics and cancer therapy.

M V Relling, T Dervieux

Journal: Nature reviews. Cancer 2002;1(2):99-108

PMID: 11905809

Full Text on Nature Publishing Group View on PubMed

Abstract

Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized dosage determination and fewer adverse effects.

Address: Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. [email protected]

DOI: 10.1038/35101056

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

https://doi.org/10.1038/35101056

MeSH Terms: ATP-Binding Cassette Transporters, Antimetabolites, Antineoplastic, Antineoplastic Agents, Biotransformation, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Folic Acid Antagonists, Forecasting, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Hypoxanthine Phosphoribosyltransferase, Methyltransferases, Neoplasms, Pharmacogenetics, Polymorphism, Single Nucleotide, Receptors, Drug, Transferases