Sustained Remission of Eosinophilic Esophagitis Following Discontinuation of Dietary Elimination in Children.

Assaf Hoofien, Alexandra Papadopoulou, Carolina Gutiérrez-Junquera, Maria José Martínez Gómez, Gloria Domínguez-Ortega, Johanna Oudshoorn, Eleftheria Roma, Jorge Amil Dias, Salvatore Oliva, Luba Marderfeld, Noam Zevit

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021;18(1):249-251.e1

PMID: 30880275

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Abstract

Eosinophilic esophagitis (EoE), when left untreated, may progress from an inflammatory to a fibrostenotic phenotype. Inflammation generally recurs after treatment withdrawal. Thus, long-term treatment has been recommended. Here, we describe a cohort of children with EoE who achieved clinical and histologic remission with elimination diets, and maintained sustained untreated remission (SUR) despite re-introduction of all eliminated food allergens.

Address: Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; Division of Gastroenterology and Hepatology, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens, Greece.; Pediatric Gastroenterology Unit, University Hospital Puerta de Hierro-Majadahonda, Madrid, Spain.; Gastroenterology and Nutrition Department, Niño Jesús University Children Hospital, Madrid, Spain.; Pediatrics, Gelre Hospitals, Apeldoorn, The Netherlands.; First Department of Pediatrics, University of Athens School of Medicine, Mitera Children's Hospital, Athens, Greece.; Pediatric Gastroenterology Unit, Centro Hospitalar São João, Porto, Portugal.; Department of Pediatrics, Sapienza University of Rome, Rome, Italy.; Nutrition and Dietetics Department, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; Institute of Gastroenterology, Nutrition, and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: [email protected].

DOI: 10.1016/j.cgh.2019.03.008

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MeSH Terms: Allergens, Child, Eosinophilic Esophagitis, Food, Food Hypersensitivity, Humans, Remission Induction, Withholding Treatment