Food components and environmental chemicals of inhibiting human placental aromatase.

Yiyan Wang, Peipei Pan, Xiaoheng Li, Qiqi Zhu, Tongliang Huang, Ren-Shan Ge

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019;128():46-53

PMID: 30922969

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Abstract

Human placental CYP19A1 catalyzes the estrogen synthesis from androgens. The enzyme is encoded by CYP19A1 gene located in chromosome 15q21. This enzyme is a monooxygenase in the smooth endoplasmic reticulum. The various promoters of the CYP19A1 gene determine its expression in different tissues and the distal promoter I.1 controls its expression in the placenta and retinoids can regulate the expression. Many food components and environmental chemicals inhibit CYP19A1 activity via different modes of action. These chemicals include gossypol, flavones, flavanones, chalconoids, resveratrol, and tobacco alkaloids derived from foods as well as phthalates, insecticides, fungicides, and biocides in the contaminated foods. The inhibition of placental CYP19A1 could impair pregnancy.

Address: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: [email protected].

DOI: 10.1016/j.fct.2019.03.043

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MeSH Terms: Aromatase, Aromatase Inhibitors, Environmental Pollutants, Estrogen Receptor Modulators, Female, Food Analysis, Humans, Placenta, Pregnancy, Promoter Regions, Genetic