Effects of vitamin D supplementation on metabolic and endocrine parameters in healthy premenopausal women: A randomized controlled trial.

Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Julia Münzker, Stefan Pilz, Thomas R Pieber, Annemieke C Heijboer, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum

Journal: Clinical nutrition (Edinburgh, Scotland) 2021;39(3):718-726

PMID: 30940404

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND & AIMS

Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc).

METHODS

The current study was a single-center, double-blind, randomized placebo-controlled trial that was conducted at the Medical University of Graz, Austria, between March 2013 and October 2017. One-hundred and fifty healthy premenopausal women with 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L once weekly received either 20,000 IU of cholecalciferol or placebo (2:1 ratio) over a total of 24 weeks.

RESULTS

In total, 127 women [age 36.2 ± 8.7 years; BMI 25.3 ± 5.6 kg/m; baseline 25(OH)D 55.8 ± 19.7 nmol/L] completed the study. Vitamin D supplementation had no significant effect on AUCgluc (mean treatment effect 11.70; p = 0.069), while it had a significant treatment effect on homeostatic model assessment-insulin resistance (HOMA-IR; mean treatment effect 0.31; p = 0.019) and quantitative insulin-sensitivity check index (QUICKI; mean treatment effect -0.019; p = 0.013). There was no significant effect on the remaining secondary outcome parameters.

CONCLUSIONS

In this randomized-controlled trial in healthy premenopausal women, there was a significant treatment effect of vitamin D supplementation on HOMA-IR and QUICKI, while there was no significant treatment effect on AUCgluc.

Address: Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].; Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria. Electronic address: [email protected].; Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria; Department of Medicine, Integrated Research and Treatment Centre for Adiposity Diseases, Leipzig University, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].; Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, De Boelelaan 1117, 1081, HV, Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Laboratory of Endocrinology, Department of Clinical Chemistry, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. Electronic address: [email protected].

DOI: 10.1016/j.clnu.2019.03.007

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MeSH Terms: Adult, Austria, Blood Glucose, Dietary Supplements, Double-Blind Method, Female, Humans, Premenopause, Vitamin D, Vitamins