Advances in Understanding the Immunological Pathways in Psoriasis.

Simona-Roxana Georgescu, Mircea Tampa, Constantin Caruntu, Maria-Isabela Sarbu, Cristina-Iulia Mitran, Madalina-Irina Mitran, Clara Matei, Carolina Constantin, Monica Neagu

Journal: International journal of molecular sciences 2019;20(3):739

PMID: 30744173

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Abstract

Psoriasis vulgaris is a chronic, immune-mediated, inflammatory, polygenic skin disorder affecting approximately 2% of the population. It has a great impact on quality of life; patients often experience depression, anxiety, stigma as well as suicidal behavior. Even though psoriasis is one of the most studied dermatological conditions, the pathogenesis of the disease is still not completely elucidated. The complex interactions between keratinocytes, dendritic cells, T-lymphocytes, neutrophils and mast cells are responsible for the histopathological changes seen in psoriasis. The pathogenic model leading to the formation of psoriatic plaques has however evolved a lot over the years. There is now enough evidence to support the role of interleukin (IL) -23, IL-17, IL-22, T helper (Th) -17 cells, Th-22 cells, T regulatory cells, transforming growth factor (TGF)-β1 and IL-10 in the pathogenesis of the disease. Moreover, several inflammatory and anti-inflammatory molecules are currently being investigated, some of them showing promising results. The aim of this paper is to look over the most recent advances in the immunological pathways involved in the pathogenesis of psoriasis vulgaris.

Address: Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Dermatology, Victor Babes Hospital of Infectious Diseases, 030303 Bucharest, Romania. [email protected].; Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Dermatology, Victor Babes Hospital of Infectious Diseases, 030303 Bucharest, Romania. [email protected].; Department of Physiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Dermatology, Prof. N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania. [email protected].; Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania. [email protected].; Department of Immunology, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania. [email protected].; Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania. [email protected].; Department of Immunology, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania. [email protected].; Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania. [email protected].; Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania. [email protected].

DOI: 10.3390/ijms20030739

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https://medlineplus.gov/psoriasis.html

MeSH Terms: Biomarkers, Cytokines, Disease Susceptibility, Humans, Immunity, Inflammation Mediators, Psoriasis, T-Lymphocyte Subsets, Th17 Cells