Chemoprevention in Prostate Cancer: Current Perspective and Future Directions.

J Ricardo Rivero, Ian M Thompson, Michael A Liss, Dharam Kaushik

Journal: Cold Spring Harbor perspectives in medicine 2019;8(10):a030494

PMID: 29311128

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Abstract

Chemoprevention of prostate cancer aims to reduce the mortality as well as the public burden of overdetection, which increases anxiety, cost, and morbidity related to the disease. The role of 5-α-reductase inhibitors has been well investigated and shown to decrease the risk of prostate cancer. No current evidence exists to encourage the use of nutrients or vitamins as chemopreventive agents. The modulation of inflammation is one of the most promising targets for chemoprevention of prostate cancer.

Address: Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.; Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.

DOI: 10.1101/cshperspect.a030494