Trefoil Factor Family: Unresolved Questions and Clinical Perspectives.

Nayara Braga Emidio, Werner Hoffmann, Stuart M Brierley, Markus Muttenthaler

Journal: Trends in biochemical sciences 2019;44(5):387-390

PMID: 30792027

Abstract

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

Copyright © 2019 Elsevier Ltd. All rights reserved.

Address: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; Authors contributed equally.; Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany; Authors contributed equally.; Visceral Pain Research Group, Centre for Neuroscience, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, 5042, Australia; Hopwood Centre for Neurobiology and Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria. Electronic address: [email protected].
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