Plasma phospholipid fatty acids are associated with altered fibrin clot properties in a population-based setting.

Z de Lange, B Kahler, C M Smuts, M Pieters

Journal: Prostaglandins, leukotrienes, and essential fatty acids 2020;143():1-7

PMID: 30975377

Full Text on Elsevier Science View on PubMed

Abstract

Evidence regarding the relationship of plasma clot properties with fatty acids is contradictory, owing to different experimental protocols employed. The relationship of fibrinogen and plasma fibrin clot properties with plasma phospholipid fatty acids were cross-sectionally investigated in a population-based setting in 900 individuals. Composite saturated fatty acids (driven by stearic acid) and composite n-3 and n-6 polyunsaturated fatty acids (driven by docosahexaenoic and arachidonic acid respectively) were associated with prothrombotic clot properties. Composite monounsaturated fatty acids (driven by oleic acid) were associated with a profibrinolytic clot phenotype. Fibrinogen and BMI partly mediated these relationships. Individual plasma fatty acids from the same composite group had opposing associations with clot properties indicating that associations with composite fatty acid groups is dependent on the relative composition of the comprising fatty acids. The relationship of the plasma phospholipid fatty acid profile with disease should not be interpreted without considering the role of regulatory mechanisms.

Address: Centre of Excellence for Nutrition, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address: [email protected].; Centre of Excellence for Nutrition, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.; Centre of Excellence for Nutrition, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address: [email protected].; Centre of Excellence for Nutrition, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address: [email protected].

DOI: 10.1016/j.plefa.2019.02.001

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MeSH Terms: Blood Coagulation, Body Mass Index, Cross-Sectional Studies, Fatty Acids, Female, Fibrin, Fibrin Clot Lysis Time, Fibrinogen, Humans, Male, Middle Aged, Nephelometry and Turbidimetry, Osmolar Concentration, Phospholipids, South Africa, Thrombosis