The role of lamin A/C in mesenchymal stem cell differentiation.

Bo Zhang, Yang Yang, Reziwan Keyimu, Jin Hao, Zhihe Zhao, Rui Ye

Journal: Journal of physiology and biochemistry 2019;75(1):11-18

PMID: 30706289

Abstract

Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.

Address: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Department of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Program in Biological Sciences in Dental Medicine, Harvard School of Dental Medicine, Boston, MA, USA.; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [email protected].; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [email protected].; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [email protected].; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [email protected].

DOI: 10.1007/s13105-019-00661-z

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https://dx.doi.org/10.1007/s13105-019-00661-z

MeSH Terms: Acyltransferases, Adaptor Proteins, Signal Transducing, Adipocytes, Adipogenesis, Cell Differentiation, Cell Nucleus, Gene Expression Regulation, Humans, Lamin Type A, Mechanotransduction, Cellular, Mesenchymal Stem Cells, Osteoblasts, Osteogenesis, Osteoporosis, Phosphoproteins, Receptors, Retinoic Acid, Serum Response Factor, Trans-Activators, Transcription Factors, Tretinoin, YAP-Signaling Proteins