Integrin as a Molecular Target for Anti-cancer Approaches in Lung Cancer.

Nithikoon Aksorn, Pithi Chanvorachote

Journal: Anticancer research 2019;39(2):541-548

PMID: 30711928

Abstract

Integrins are cell-matrix adhesion molecules providing both mechanical engagement of cell to extracellular matrix, and generation of cellular signals that are implicated in cancer malignancies. The concept that integrins play important roles in cell survival, proliferation, motility, differentiation, and ensuring appropriate cell localization, leads to the hypothesis that inhibition of certain integrins would benefit cancer therapy. In lung cancer, integrins αv, α5, β1, β3, and β5 have been shown to augment survival and metastatic potential of cancer cells. This review presents data suggesting integrins as molecular targets for anti-cancer approaches, and the mechanisms through which integrins confer resistance of lung cancer to chemotherapeutics and metastasis. The better understanding of these key molecules may benefit the discovery of anti-cancer drugs and strategies.

Address: Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand [email protected] [email protected].; Cell-based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

DOI: 10.21873/anticanres.13146

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MeSH Terms: Antineoplastic Agents, Cell Adhesion, Cell Differentiation, Cell Proliferation, Cell Survival, Curcumin, Disease Progression, Extracellular Matrix, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Integrins, Lung Neoplasms, Neoplasm Metastasis, Ouabain, Phloretin, Xanthones