Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.

Andrew P Koutnik, Dominic P D'Agostino, Brendan Egan

Journal: Trends in endocrinology and metabolism: TEM 2020;30(4):227-229

PMID: 30712977

Full Text on Elsevier Science View on PubMed

Abstract

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

Address: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.; National Institute for Cellular Biotechnology, School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address: [email protected].

DOI: 10.1016/j.tem.2019.01.006

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MeSH Terms: 3-Hydroxybutyric Acid, Acetoacetates, Diet, Ketogenic, Humans, Inflammation, Ketone Bodies, Ketosis, Muscle, Skeletal