Microbial transformation of chiral organohalides: Distribution, microorganisms and mechanisms.

Qihong Lu, Lan Qiu, Ling Yu, Shangwei Zhang, Renata Alves de Toledo, Hojae Shim, Shanquan Wang

Journal: Journal of hazardous materials 2020;368():849-861

PMID: 30772625

Full Text on Elsevier Science View on PubMed

Abstract

Chiral organohalides including dichlorodiphenyltrichloroethane (DDT), Hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) raise a significant concern in the environmental occurrence, fate and ecotoxicology due to their enantioselective biological effects. This review provides a state-of-the-art overview on enantioselective microbial transformation of the chiral organohalides. We firstly summarized worldwide field assessments of chiral organohalides in a variety of environmental matrices, which suggested the pivotal role of microorganisms in enantioselective transformation of chiral organohalides. Then, laboratory studies provided experimental evidences to further link enantioselective attenuation of chiral organohalides to specific functional microorganisms and enzymes, revealing mechanistic insights into the enantioselective microbial transformation processes. Particularly, a few amino acid residues in the functional enzymes could play a key role in mediating the enantioselectivity at the molecular level. Finally, major challenges and further developments toward an in-depth understanding of the enantioselective microbial transformation of chiral organohalides are identified and discussed.

Address: School of Environmental Science and Engineering, Sun Yat-Sen University, 510275 Guangzhou, China; Environmental Microbiome Research Center, Sun Yat-Sen University, 510275 Guangzhou, China.; School of Environmental Science and Engineering, Sun Yat-Sen University, 510275 Guangzhou, China.; UFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstraße 15, 04318 Leipzig, Germany.; Department of Civil and Environmental Engineering, Faculty of Science and Technology, University of Macau, 999078 Macau SAR, China.; School of Environmental Science and Engineering, Sun Yat-Sen University, 510275 Guangzhou, China; Environmental Microbiome Research Center, Sun Yat-Sen University, 510275 Guangzhou, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, 510275 Guangzhou, China. Electronic address: [email protected].

DOI: 10.1016/j.jhazmat.2019.01.103

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MeSH Terms: Biodegradation, Environmental, Environmental Pollutants, Hydrocarbons, Halogenated, Stereoisomerism