Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis.

Christopher Perry, Emmanuel L C de Los Santos, Lona M Alkhalaf, Gregory L Challis

Journal: Natural product reports 2019;35(7):622-632

PMID: 29651484

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Covering: up to the end of 2017 The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C-C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.

Address: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. [email protected] [email protected].

DOI: 10.1039/c8np00004b

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https://doi.org/10.1039/c8np00004b

MeSH Terms: Biological Products, Cyclization, Electron Transport Complex III, Heme, Heterocyclic Compounds, 3-Ring, Hydroxylation, Oxygenases, Prodigiosin, Pyrroles, Pyrrolnitrin, Spiro Compounds