Meta-analysis for assessing the healing process of ulcers among diabetic patients: Cases of HbA1c, lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, 25-hydroxy vitamin D.

Mohammad Zubair, Jamal Ahmad

Journal: Diabetes & metabolic syndrome 2019;13(1):810-814

PMID: 30641813

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

The study aims to investigate the significance of predictors including HbA1c, Lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, and 25-hydroxy vitamin D and to evaluate the rate of healing of ulcers among the diabetic foot patients.

METHODS

A retrospective method is used to quantitatively assess the role of HbA1c, Lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, and 25-hydroxy vitamin D in the healing process of ulcer among diabetic patients. A total of 192 diabetic patients were included, who underwent ulcer healing diagnosis.

RESULTS

The results have shown a positive and significant correlation between Adiponectin and Cat D with group 2. The findings have shown higher prevalence of Cad D among patients with group 1, HSP70 among patients with group 2, HSP47 among patients with group 2, and 25-hydroxy vitamin D among patients with group 1.

CONCLUSION

The study concluded that insignificant predictors should be assessed more comprehensively to reveal its efficacy on healing of ulcers with different grades.

Address: Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk, 71491, Saudi Arabia. Electronic address: [email protected].; Rajiv Gandhi Centre for Diabetes and Endocrinology, J N. Medical College, Aligarh Muslim University, Aligarh 202002, India.

DOI: 10.1016/j.dsx.2018.12.004

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MeSH Terms: Adiponectin, Adult, Aged, Biomarkers, Cathepsin D, Cohort Studies, Creatinine, Diabetic Foot, Female, Glycated Hemoglobin, Glycolipids, HSP47 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Humans, Male, Middle Aged, Prospective Studies, Vitamin D