Genotypic and Phenotypic Aspects of Longevity: Results from a Sicilian Survey and Implication for the Prevention and Treatment of Age-related Diseases.

Giulia Accardi, Stefano Aprile, Giuseppina Candore, Calogero Caruso, Rosanna Cusimano, Laura Cristaldi, Danilo Di Bona, Giovanni Duro, Damiano Galimberti, Caterina Maria Gambino, Mattia Emanuela Ligotti, Walter Mazzucco, Sonya Vasto, Anna Aiello

Journal: Current pharmaceutical design 2020;25(3):228-235

PMID: 30864497

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Abstract

BACKGROUND

It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to a long and healthy life is of tremendous interest for translational medicine.

METHODS

We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long-lived individuals.

RESULTS

We review the characteristics of longevity in Sicily, taking into account lifestyle, environment, genetics, hematochemical values, body composition and immunophenotype. In addition, we discuss the possible implications of our data for the prevention and/or treatment of age-related diseases.

CONCLUSION

As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and/or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a "positive biology" approach, how to prevent and/or reduce elderly frailty and disability.

Address: Section of General Pathology, Department of Biomedicine, Neurosciences and Advanced Technologies, University of Palermo, Corso Tukory 211, Palermo 90134, Italy.; Italian Association of Anti-Ageing Physicians, Via Monte Cristallo, 1, 20159 Milano, Italy.; Local Health Unit 6, via Giacomo Cusmano, 24, 90141 Palermo, Italy.; Institute of Biomedicine and Molecular Immunology "Alberto Monroy", National Research Council, Via Ugo La Malfa, 153, 90146 Palermo, Italy.; Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Piazza G. Cesare, 11, 70124 Bari, Italy.; Department of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, via del Vespro, 133 Palermo, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Parco d'Orleans, Edificio 16, 90128, Palermo, Italy.

DOI: 10.2174/1381612825666190313115233

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MeSH Terms: Aging, Genotype, Humans, Life Style, Longevity, Phenotype, Sicily, Surveys and Questionnaires